Rational design, synthesis, molecular modeling, biological activity, and mechanism of action of polypharmacological norfloxacin hydroxamic acid derivatives
نویسندگان
چکیده
Fluoroquinolones are broad-spectrum antibiotics that target gyrase and topoisomerase IV, involved in DNA compaction segregation. We synthesized 28 novel norfloxacin hydroxamic acid derivatives with additional metal-chelating hydrophobic pharmacophores,...
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ژورنال
عنوان ژورنال: RSC medicinal chemistry
سال: 2023
ISSN: ['2632-8682']
DOI: https://doi.org/10.1039/d3md00309d